Notch Signaling Augments BMP9-Induced Bone Formation by Promoting the Osteogenesis-Angiogenesis Coupling Process in Mesenchymal Stem Cells (MSCs)

20172,751 citationsJournal Articlegold Open Access

Authors

Junyi Liao · First Affiliated Hospital of Chongqing Medical University

Qiang Wei · Chongqing Medical University

Yulong Zou · First Affiliated Hospital of Chongqing Medical University

Jiaming Fan · University of Chicago Medical Center

Dongzhe Song · University of Chicago Medical Center

Jing Cui · University of Chicago Medical Center

Wenwen Zhang

Abstract

Notch signaling may play an important role in BMP9-induced osteogenesis and angiogenesis. It's conceivable that simultaneous activation of the BMP9 and Notch pathways should efficiently couple osteogenesis and angiogenesis of MSCs for successful bone tissue engineering.

Topics & Keywords

TGF-β signaling in diseases Developmental Biology and Gene Regulation Mesenchymal stem cell research

Publication Details

Published in: Cellular Physiology and Biochemistry

Volume 41, Issue 5, pp. 1905-1923

DOI: 10.1159/000471945

Field-Weighted Citation Impact: 102.34

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Notch Signaling Augments BMP9-Induced Bone Formation by Promoting the Osteogenesis-Angiogenesis Coupling Process in Mesenchymal Stem Cells (MSCs)

Authors

Abstract

Topics & Keywords

Publication Details