Association Between Midlife Vascular Risk Factors and Estimated Brain Amyloid Deposition

2017652 citationsJournal Article

Authors

Rebecca F. Gottesman · Johns Hopkins University

Andrea L.C. Schneider · Johns Hopkins University

Yun Zhou · Johns Hopkins Medicine

Josef Coresh · Johns Hopkins University

Edward Green · University of Mississippi Medical Center

Naresh Gupta · Hagerstown Community College

David S. Knopman

Abstract

An increasing number of midlife vascular risk factors was significantly associated with elevated amyloid SUVR; this association was not significant for late-life risk factors. These findings are consistent with a role of vascular disease in the development of Alzheimer disease.

Topics & Keywords

Dementia and Cognitive Impairment Research Functional Brain Connectivity Studies Cerebrovascular and Carotid Artery Diseases

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: JAMA

Volume 317, Issue 14, pp. 1443-1443

DOI: 10.1001/jama.2017.3090

Field-Weighted Citation Impact: 44.01