Distinct Regulatory Effects of Myeloid Cell and Endothelial Cell NAPDH Oxidase 2 on Blood Pressure

201761 citationsJournal Articlegreen Open Access

Authors

Can Martin Sag · Nephrologisches Zentrum Goettingen

Moritz Schnelle · Nephrologisches Zentrum Goettingen

Juqian Zhang · Nephrologisches Zentrum Goettingen

Colin E. Murdoch · Nephrologisches Zentrum Goettingen

Sabine Kossmann · Nephrologisches Zentrum Goettingen

Andrea Protti · Nephrologisches Zentrum Goettingen

Célio X.C. Santos

Abstract

We identify a hitherto unrecognized modulation of basal BP by myeloid cell Nox2, whereas endothelial cell Nox2 regulates angiotensin II-induced hypertension. These results identify distinct cell-specific roles for Nox2 in BP regulation.

Topics & Keywords

Sodium Intake and Health Nitric Oxide and Endothelin Effects Eicosanoids and Hypertension Pharmacology

UN Sustainable Development Goals

Life below water

Publication Details

Published in: Circulation

Volume 135, Issue 22, pp. 2163-2177

DOI: 10.1161/circulationaha.116.023877

Field-Weighted Citation Impact: 4.84