Synovial and systemic pharmacokinetics (PK) of triamcinolone acetonide (TA) following intra-articular (IA) injection of an extended-release microsphere-based formulation (FX006) or standard crystalline suspension in patients with knee osteoarthritis (OA)

2017135 citationsJournal Articlehybrid Open Access

Authors

Virginia B. Kraus · Duke University

Philip G. Conaghan · NIHR Leeds Musculoskeletal Biomedical Research Unit

H.A. Aazami

P. Mehra · Artemis (United States)

Alan Kivitz · Altoona Center for Clinical Research

Joelle Lufkin · Flexion Therapeutics (United States)

J. Hauben · Flexion Therapeutics (United States)

Abstract

In knee OA patients, microsphere-based TA delivery via a single IA injection prolonged SF joint residency, diminished peak plasma levels, and thus reduced systemic TA exposure relative to TAcs.

Topics & Keywords

Osteoarthritis Treatment and Mechanisms Inflammatory mediators and NSAID effects Analytical Methods in Pharmaceuticals

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Osteoarthritis and Cartilage

Volume 26, Issue 1, pp. 34-42

DOI: 10.1016/j.joca.2017.10.003

Field-Weighted Citation Impact: 9.63