Pathology of callosal damage in ALS: An ex-vivo, 7 T diffusion tensor MRI study

201764 citationsJournal Articlegold Open Access

Authors

Agustín M. Cárdenas · National Institute of Neurological Disorders and Stroke

Joelle E. Sarlls · National Institute of Neurological Disorders and Stroke

Justin Kwan · University of Maryland, Baltimore

Devin Bageac · National Institute of Neurological Disorders and Stroke

Zachary Gala · National Institute of Neurological Disorders and Stroke

Laura E. Danielian · National Institute of Neurological Disorders and Stroke

Abstract

Reduced FA of the corpus callosum in ALS results from complex changes in tissue microstructure. Callosal segments with reduced FA had large numbers of microglia-macrophages in addition to loss of myelinated axons and astrogliosis. Microglial inflammation contributed to reduced FA in ALS, and may contribute to a pro-inflammatory state, but further work is needed to determine their role.

Topics & Keywords

Advanced Neuroimaging Techniques and Applications Bone and Joint Diseases Spinal Dysraphism and Malformations

Publication Details

Published in: NeuroImage Clinical

Volume 15, pp. 200-208

DOI: 10.1016/j.nicl.2017.04.024

Field-Weighted Citation Impact: 4.28

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Pathology of callosal damage in ALS: An ex-vivo, 7 T diffusion tensor MRI study

Authors

Abstract

Topics & Keywords

Publication Details