Metformin as targeted treatment in fragile X syndrome

2017118 citationsJournal Articlegreen Open Access

Authors

Angel Belle C. Dy · Ateneo de Manila University

Flora Tassone · University of California Davis Medical Center

Mona Kamal Eldeeb · University of California Davis Medical Center

María Jimena Salcedo‐Arellano · University of California Davis Medical Center

Nicole Tartaglia · University of Colorado Denver

Randi J. Hagerman · University of California Davis Medical Center

Abstract

We recommend a controlled trial of metformin in those with FXS. Metformin appears to be an effective treatment of obesity including those with the PWP in FXS. Our study suggests that metformin may also be a targeted treatment for improving behavior and language in children and adults with FXS.

Topics & Keywords

Genetics and Neurodevelopmental Disorders Pancreatic function and diabetes Autism Spectrum Disorder Research

UN Sustainable Development Goals

Quality Education

Publication Details

Published in: Clinical Genetics

Volume 93, Issue 2, pp. 216-222

DOI: 10.1111/cge.13039

Field-Weighted Citation Impact: 9.27