2P267 Re-docking scheme for prediction of protein-protein interactions using interaction fingerprints(22A. Bioinformatics: Structural genomics,Poster)

Recent progress in molecular biology and genome science leads to finding many functional RNAs which control gene expression and replication.These functions are achieved through the protein-RNA and RNA-RNA interactions.Deriving the tertiary structures of these complex is very helpful to clarify the mechanism of those functions in detail.We developed the new method based on fragment assembly algorithm to predict RNA-RNA complex structures from nucleotide sequence and secondary structure information.We applied our method to predict several kinds of RNA-RNA complex structures which include kissing-loops, hammerhead ribozymes and other difficult targets, and derived successful results especially in the prediction of kissing-loop targets.