Anti–Cyclic Citrullinated Peptide Antibodies in Advanced Rheumatoid Arthritis

Letters5 August 2003Anti–Cyclic Citrullinated Peptide Antibodies in Advanced Rheumatoid ArthritisGeraldo Castelar Pinheiro, MD, Morton A. Scheinberg, MD, PhD, Miriam Aparecida da Silva, BS, and Suely Maciel, BSGeraldo Castelar Pinheiro, MDUniversidade Estadual do Rio de Janeiro; Rio de Janeiro, Brazil (Castelar, Pinheiro)Hospital Israelita Albert Einstein; Sao Paulo, Brazil (Scheinberg)L.I.D. Laboratory; Sao Paulo, Brazil (Aparecida da Silva, Maciel), Morton A. Scheinberg, MD, PhDUniversidade Estadual do Rio de Janeiro; Rio de Janeiro, Brazil (Castelar, Pinheiro)Hospital Israelita Albert Einstein; Sao Paulo, Brazil (Scheinberg)L.I.D. Laboratory; Sao Paulo, Brazil (Aparecida da Silva, Maciel), Miriam Aparecida da Silva, BSUniversidade Estadual do Rio de Janeiro; Rio de Janeiro, Brazil (Castelar, Pinheiro)Hospital Israelita Albert Einstein; Sao Paulo, Brazil (Scheinberg)L.I.D. Laboratory; Sao Paulo, Brazil (Aparecida da Silva, Maciel), and Suely Maciel, BSUniversidade Estadual do Rio de Janeiro; Rio de Janeiro, Brazil (Castelar, Pinheiro)Hospital Israelita Albert Einstein; Sao Paulo, Brazil (Scheinberg)L.I.D. Laboratory; Sao Paulo, Brazil (Aparecida da Silva, Maciel)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-139-3-200308050-00021 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Background: Rheumatoid arthritis is a chronic systemic autoimmune disease of unknown cause. There is growing evidence that therapeutic intervention early in the disease course leads to better control and less joint damage. With more sophisticated types of therapy becoming available, it is now even more important to definitively diagnose rheumatoid arthritis at an early stage so that treatment can be administered sooner and major damage of joint tissue can be prevented (1). A disease-specific autoantibody that could be used as a serologic marker of the disease would be very useful.Rheumatoid factor combined with clinical findings has ...References1. Keystone E. Treatments no longer in development for rheumatoid arthritis. Ann Rheum Dis. 2002;61 Suppl 2 ii43-5. [PMID: 12379620] CrossrefMedlineGoogle Scholar2. Bizzaro N, Mazzanti G, Tonutti E, Villalta D, Tozzoli R. Diagnostic accuracy of the anti-citrulline antibody assay for rheumatoid arthritis. Clin Chem. 2001;47:1089-93. [PMID: 11375296] CrossrefMedlineGoogle Scholar3. Kroot EJ, de Jong BA, van Leeuwen MA, Swinkels H, van den Hoogen FH, van't Hof M, . The prognostic value of anti-cyclic citrullinated peptide antibody in patients with recent-onset rheumatoid arthritis. Arthritis Rheum. 2000;43:1831-5. [PMID: 10943873] CrossrefMedlineGoogle Scholar4. van der Heijde DM, van 't Hof M, van Riel PL, van de Putte LB. Development of a disease activity score based on judgment in clinical practice by rheumatologists. J Rheumatol. 1993;20:579-81. [PMID: 8478878] MedlineGoogle Scholar5. Pinheiro GR, Andrade CA, Gayer CR, Coelho MS, Freire SM, Scheinberg MA. Serum vascular endothelial growth factor in late rheumatoid arthritis. Clin Exp Rheumatol. 2001;19:721-3. [PMID: 11791646] MedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Universidade Estadual do Rio de Janeiro; Rio de Janeiro, Brazil (Castelar, Pinheiro)Hospital Israelita Albert Einstein; Sao Paulo, Brazil (Scheinberg)L.I.D. 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