Electronic cigarette aerosols suppress cellular antioxidant defenses and induce significant oxidative DNA damage

2017170 citationsJournal Articlegold Open Access

Authors

Vengatesh Ganapathy · University of Oklahoma Health Sciences Center

Jimmy Manyanga · University of Oklahoma Health Sciences Center

Lacy S. Brame · University of Oklahoma Health Sciences Center

Dehra McGuire · University of Oklahoma Health Sciences Center

Balaji Sadhasivam · University of Oklahoma Health Sciences Center

Evan L. Floyd · University of Oklahoma Health Sciences Center

David A. Rubenstein

Abstract

Exposure to EC aerosol extracts suppressed the cellular antioxidant defenses and led to significant DNA damage. These findings emphasize the urgent need to investigate the potential long-term cancer risk of exposure to EC aerosol for vapers and the general public.

Topics & Keywords

Smoking Behavior and Cessation Carcinogens and Genotoxicity Assessment Air Quality and Health Impacts

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: PLoS ONE

Volume 12, Issue 5, pp. e0177780-e0177780

DOI: 10.1371/journal.pone.0177780

Field-Weighted Citation Impact: 11.35