Recovery of ethanol-induced Akkermansia muciniphila depletion ameliorates alcoholic liver disease

2017597 citationsJournal Article

Authors

Christoph Grander · Innsbruck Medical University

Timon E. Adolph · Innsbruck Medical University

Verena Wieser · Innsbruck Medical University

Patrick Lowe · University of Massachusetts Chan Medical School

Laura Wrzosek · Inserm

Benedek Gyöngyösi · University of Massachusetts Chan Medical School

Doyle V. Ward

Abstract

Ethanol exposure diminishes intestinal A. muciniphila abundance in both mice and humans and can be recovered in experimental ALD by oral supplementation. A. muciniphila promotes intestinal barrier integrity and ameliorates experimental ALD. Our data suggest that patients with ALD might benefit from A. muciniphila supplementation.

Topics & Keywords

Alcohol Consumption and Health Effects Gut microbiota and health Liver Disease Diagnosis and Treatment

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Gut

Volume 67, Issue 5, pp. 891-901

DOI: 10.1136/gutjnl-2016-313432

Field-Weighted Citation Impact: 32.84

Command Palette

Recovery of ethanol-induced <i>Akkermansia muciniphila</i> depletion ameliorates alcoholic liver disease

Authors

Abstract

Topics & Keywords

UN Sustainable Development Goals

Publication Details