A segmented flow platform for on-demand medicinal chemistry and compound synthesis in oscillating droplets

201789 citationsJournal Article

Authors

Ye‐Jin Hwang · Inha University

Connor W. Coley · Massachusetts Institute of Technology

Milad Abolhasani · North Carolina State University

Andreas L. Marzinzik · Novartis (Switzerland)

Guido Koch · Novartis (Switzerland)

Carsten Spanka · Novartis (Switzerland)

Hansjoerg Lehmann ·

Abstract

We report an automated flow chemistry platform that can efficiently perform a wide range of chemistries, including single/multi-phase and single/multi-step, with a reaction volume of just 14 μL. The breadth of compatible chemistries is successfully demonstrated and the desired products are characterized, isolated, and collected online by preparative HPLC/MS/ELSD.

Topics & Keywords

Innovative Microfluidic and Catalytic Techniques Innovation Microfluidic and Capillary Electrophoresis Applications Electrowetting and Microfluidic Technologies

Publication Details

Published in: Chemical Communications

Volume 53, Issue 49, pp. 6649-6652

DOI: 10.1039/c7cc03584e

Field-Weighted Citation Impact: 5.89

Command Palette

A segmented flow platform for on-demand medicinal chemistry and compound synthesis in oscillating droplets

Authors

Abstract

Topics & Keywords

Publication Details