Pirfenidone inhibits myofibroblast differentiation and lung fibrosis development during insufficient mitophagy

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Authors

Yusuke Kurita · Jikei University School of Medicine

Jun Araya · Jikei University School of Medicine

Shunsuke Minagawa · Jikei University School of Medicine

Hiromichi Hara · Jikei University School of Medicine

Akihiro Ichikawa · Jikei University School of Medicine

Nayuta Saito · Jikei University School of Medicine

Tsukasa Kadota

Abstract

These results suggest that PFD induces PARK2-mediated mitophagy and also inhibits lung fibrosis development in the setting of insufficient mitophagy, which may at least partly explain the anti-fibrotic mechanisms of PFD for IPF treatment.

Topics & Keywords

Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis Autophagy in Disease and Therapy

Publication Details

Published in: Respiratory Research

Volume 18, Issue 1, pp. 114-114

DOI: 10.1186/s12931-017-0600-3

Field-Weighted Citation Impact: 7.97

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Pirfenidone inhibits myofibroblast differentiation and lung fibrosis development during insufficient mitophagy

Authors

Abstract

Topics & Keywords

Publication Details