Lithium Use in Pregnancy and the Risk of Cardiac Malformations

2017254 citationsJournal Articlebronze Open Access

Authors

Elisabetta Patorno · Pharmacoeconomics and Health Outcomes Research Iberia (Spain)

Krista F. Huybrechts · Pharmacoeconomics and Health Outcomes Research Iberia (Spain)

Brian T. Bateman · Pharmacoeconomics and Health Outcomes Research Iberia (Spain)

Jacqueline M. Cohen · Brigham and Women's Hospital

Rishi Desai · Pharmacoeconomics and Health Outcomes Research Iberia (Spain)

Helen Mogun · Pharmacoeconomics and Health Outcomes Research Iberia (Spain)

Abstract

Maternal use of lithium during the first trimester was associated with an increased risk of cardiac malformations, including Ebstein's anomaly; the magnitude of this effect was smaller than had been previously postulated. (Funded by the National Institute of Mental Health.).

Topics & Keywords

Pregnancy and Medication Impact Pharmacological Effects and Toxicity Studies Maternal Mental Health During Pregnancy and Postpartum

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 376, Issue 23, pp. 2245-2254

DOI: 10.1056/nejmoa1612222

Field-Weighted Citation Impact: 28.27