Genome-wide Pleiotropy Between Parkinson Disease and Autoimmune Diseases

2017374 citationsJournal Articlebronze Open Access

Authors

Aree Witoelar · Oslo University Hospital

Iris E. Jansen · German Center for Neurodegenerative Diseases

Yunpeng Wang · University of California San Diego

Rahul S. Desikan · University of California, San Francisco

J. Raphael Gibbs · National Institute on Aging

Cornelis Blauwendraat · German Center for Neurodegenerative Diseases

Wesley K. Thompson

Abstract

The study findings provide novel mechanistic insights into PD and autoimmune diseases and identify a common genetic pathway between these phenotypes. The results may have implications for future therapeutic trials involving anti-inflammatory agents.

Topics & Keywords

Parkinson's Disease Mechanisms and Treatments Protein Tyrosine Phosphatases Genetic Associations and Epidemiology

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: JAMA Neurology

Volume 74, Issue 7, pp. 780-780

DOI: 10.1001/jamaneurol.2017.0469

Field-Weighted Citation Impact: 18.83