Unique Cardiac Purkinje Fiber Transient Outward Current β-Subunit Composition

201393 citationsJournal Articlebronze Open Access

Authors

Ling Xiao · University of Szeged

Tamara T. Koopmann · University of Szeged

Balázs Ördög · Columbia University

Pieter G. Postema · Columbia University

Arie O. Verkerk · University of Szeged

Vivek Iyer · Columbia University

Kevin J. Sampson ·

Abstract

These results point to a previously unknown central role of DPP6 in PF I(to), with DPP6 gain of function selectively enhancing PF current, and suggest that a DPP6-mediated PF early-repolarization syndrome might be a novel molecular paradigm for some forms of idiopathic ventricular fibrillation.

Topics & Keywords

Cardiac electrophysiology and arrhythmias Ion channel regulation and function Cardiac Arrhythmias and Treatments

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation Research

Volume 112, Issue 10, pp. 1310-1322

DOI: 10.1161/circresaha.112.300227

Field-Weighted Citation Impact: 6.27