Multiancestry Study of Gene–Lifestyle Interactions for Cardiovascular Traits in 610 475 Individuals From 124 Cohorts

201774 citationsJournal Articlediamond Open Access

Authors

D. C. Rao

Yan V. Sun · Yuncheng University

Thomas W. Winkler

Karen Schwander · Karen Hospital

Patricia B. Munroe · Munroe Regional Medical Center

Bruce M. Psaty

Abstract

The Gene-Lifestyle Interactions Working Group provides an excellent framework for understanding the lifestyle context of genetic effects and to identify novel trait loci through analysis of interactions. An important and novel feature of our study is that the gene-lifestyle interaction (G×E) results may improve our knowledge about the underlying mechanisms for novel and already known trait loci.

Topics & Keywords

Genetic Associations and Epidemiology Nutrition, Genetics, and Disease Birth, Development, and Health

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation Cardiovascular Genetics

Volume 10, Issue 3

DOI: 10.1161/circgenetics.116.001649

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