Regulation of Rat Heme Oxygenase–1 Gene Expression by Interleukin–6 via Jak/STAT Pathway

20051 citationsJournal Article

Authors

Kyrylo Tron · Universitätsmedizin Göttingen

Anatoly Samoylenko · University of Göttingen

Gernot Musikowski · University of Göttingen

Fritz Kobe · University of Göttingen

Stephan Immenschuh

Fred Schaper · Universitätsklinikum Aachen

Giuliano Ramadori · Universitätsmedizin Göttingen

Abstract

Background and Aims: Heme oxygenase–1 (HO–1) is the inducible enzyme that catalyzes oxidative degradation of heme. It has been recently shown that HO–1 expression is up-regulated in the liver by proinflammatory cytokines. However, the signal transduction pathways of the cytokine-dependent HO–1 regulation are not known in detail. Therefore, the aim of the present study was to investigate the mechanisms of the IL–6-mediated HO–1 induction.

Topics & Keywords

Heme Oxygenase-1 and Carbon Monoxide Neutrophil, Myeloperoxidase and Oxidative Mechanisms Immune cells in cancer

Publication Details

Published in: Zeitschrift für Gastroenterologie

Volume 43, Issue 01

DOI: 10.1055/s-2005-861609

Field-Weighted Citation Impact: 0.12

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Regulation of Rat Heme Oxygenase–1 Gene Expression by Interleukin–6 via Jak/STAT Pathway

Authors

Abstract

Topics & Keywords

Publication Details