Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease

20172,524 citationsJournal Articlegreen Open Access

Authors

Siddhartha Jaiswal · Brigham and Women's Hospital

Pradeep Natarajan · Broad Institute

Alexander J. Silver · Brigham and Women's Hospital

Christopher J. Gibson · Dana-Farber Cancer Institute

Alexander G. Bick · Massachusetts General Hospital

Eugenia Shvartz · Brigham and Women's Hospital

Marie McConkey

Abstract

The presence of CHIP in peripheral-blood cells was associated with nearly a doubling in the risk of coronary heart disease in humans and with accelerated atherosclerosis in mice. (Funded by the National Institutes of Health and others.).

Topics & Keywords

Acute Myeloid Leukemia Research Hemoglobinopathies and Related Disorders Myeloproliferative Neoplasms: Diagnosis and Treatment

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 377, Issue 2, pp. 111-121

DOI: 10.1056/nejmoa1701719

Field-Weighted Citation Impact: 125.52