Do COPD subtypes really exist? COPD heterogeneity and clustering in 10 independent cohorts

201792 citationsJournal Articlebronze Open Access

Authors

Peter J. Castaldi · Harvard University

Marta Benet · Pompeu Fabra University

Hans Petersen · COPD Foundation

Nicholas Rafaels · University of Colorado Anschutz Medical Campus

James H. Finigan · National Jewish Health

Matteo Paoletti · University of Florence

H. Marike Boezen ·

Abstract

Identical clustering analyses across multiple COPD cohorts showed modest reproducibility. COPD heterogeneity is better characterised by continuous disease traits coexisting in varying degrees within the same individual, rather than by mutually exclusive COPD subtypes.

Topics & Keywords

Chronic Obstructive Pulmonary Disease (COPD) Research Asthma and respiratory diseases Nursing Diagnosis and Documentation

Publication Details

Published in: Thorax

Volume 72, Issue 11, pp. 998-1006

DOI: 10.1136/thoraxjnl-2016-209846

Field-Weighted Citation Impact: 7.29

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Do COPD subtypes really exist? COPD heterogeneity and clustering in 10 independent cohorts

Authors

Abstract

Topics & Keywords

Publication Details