Probucol ameliorates renal injury in diabetic nephropathy by inhibiting the expression of the redox enzyme p66Shc

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Authors

Shikun Yang · Central South University

Li Zhao · Central South University

Yachun Han · Second Xiangya Hospital of Central South University

Yu Liu · Central South University

Chao Chen · Second Xiangya Hospital of Central South University

Ming Zhan · Second Xiangya Hospital of Central South University

Xiaofen Xiong

Abstract

Our results suggest for the first time that probucol ameliorates renal damage in DN by epigenetically suppressing p66Shc expression via the AMPK-SIRT1-AcH3 pathway.

Topics & Keywords

Advanced Glycation End Products research Heme Oxygenase-1 and Carbon Monoxide Sirtuins and Resveratrol in Medicine

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Redox Biology

Volume 13, pp. 482-497

DOI: 10.1016/j.redox.2017.07.002

Field-Weighted Citation Impact: 3.74