Knockdown of ARK5 Expression Suppresses Invasion and Metastasis of Gastric Cancer

201748 citationsJournal Articlegold Open Access

Authors

Dehu Chen · Affiliated Hospital of Nantong University

Guiyuan Liu · Nantong University

Ning Xu · Nantong University

Xiaolan You · Nantong University

Hai‐Hua Zhou · Nantong University

Xiaojun Zhao · Affiliated Hospital of Nantong University

Qinghong Liu ·

Abstract

The elevated ARK5 expression was closely associated with cancer metastasis and patient survival, and it seemed to function in GC cells migration and invasion via EMT alteration, together with the alteration of the mTOR/p70S6k signals, Slug and SIP1, thus providing a potential therapeutic target for GC.

Topics & Keywords

FOXO transcription factor regulation Cancer Mechanisms and Therapy Mechanisms of cancer metastasis

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Cellular Physiology and Biochemistry

Volume 42, Issue 3, pp. 1025-1036

DOI: 10.1159/000478685

Field-Weighted Citation Impact: 3.13