Cardioprotective effects of 5‐hydroxymethylfurfural mediated by inhibition of L‐type Ca2+ currents

201730 citationsJournal Articlehybrid Open Access

Authors

Gerald Wölkart · University of Graz

Astrid Schrammel · University of Graz

Chintan N. Koyani · Medical University of Graz

S Scherübel · Medical University of Graz

Klaus Zorn‐Pauly · Medical University of Graz

Ernst Malle · Medical University of Graz

Brigitte Pelzmann ·

Abstract

Our data revealed a cardioprotective effect of 5-HMF in I/R that is mediated by inhibition of L-type Ca2+ channels. Thus, 5-HMF is suggested as a beneficial additive to cardioplegic solutions, but adverse effects and contraindications of Ca2+ channel blockers have to be considered in therapeutic application of the drug.

Topics & Keywords

Phytochemicals and Antioxidant Activities Free Radicals and Antioxidants Electrochemical Analysis and Applications

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: British Journal of Pharmacology

Volume 174, Issue 20, pp. 3640-3653

DOI: 10.1111/bph.13967

Field-Weighted Citation Impact: 1.76

Command Palette

Cardioprotective effects of 5‐hydroxymethylfurfural mediated by inhibition of L‐type Ca<sup>2+</sup> currents

Authors

Abstract

Topics & Keywords

UN Sustainable Development Goals

Publication Details