Anticoagulation with warfarin and rivaroxaban ameliorates experimental autoimmune encephalomyelitis

201722 citationsJournal Articlegold Open Access

Authors

Leonie Stolz · Goethe University Frankfurt

Amin Derouiche · Goethe University Frankfurt

Kavi Devraj · Goethe University Frankfurt

Frank Weber · Capio Clinic in the Park

Robert Brunkhorst · Goethe University Frankfurt

Christian Foerch · Goethe University Frankfurt

Abstract

We developed long-term anticoagulation models that allowed exploring the course of EAE under warfarin and rivaroxaban treatment. We found a mild preventive effect of both warfarin and rivaroxaban on neurological deficits and local inflammation, indicating a modulation of the disease induction by anticoagulation.

Topics & Keywords

Blood Coagulation and Thrombosis Mechanisms Venous Thromboembolism Diagnosis and Management Myeloproliferative Neoplasms: Diagnosis and Treatment

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of Neuroinflammation

Volume 14, Issue 1, pp. 152-152

DOI: 10.1186/s12974-017-0926-2

Field-Weighted Citation Impact: 1.44