Childhood adiposity and risk of type 1 diabetes: A Mendelian randomization study

2017123 citationsJournal Articlegold Open Access

Authors

Jenny C. Censin · Science for Life Laboratory

Christoph Nowak · Uppsala University

Nicholas Cooper · University of Cambridge

Peter Bergsten · Uppsala University

John A. Todd · Wellcome Trust

Tove Fall · Science for Life Laboratory

Abstract

This study provides genetic support for a link between childhood adiposity and T1D risk. Together with evidence from observational studies, our findings further emphasize the importance of measures to reduce the global epidemic of childhood obesity and encourage mechanistic studies.

Topics & Keywords

Diabetes and associated disorders Genetic Associations and Epidemiology Pancreatic function and diabetes

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: PLoS Medicine

Volume 14, Issue 8, pp. e1002362-e1002362

DOI: 10.1371/journal.pmed.1002362

Field-Weighted Citation Impact: 8.80