Induction of the Vitamin D Receptor Attenuates Autophagy Dysfunction-Mediated Cell Death Following Traumatic Brain Injury.

20175,188 citationsJournal Article

Authors

Changmeng Cui · Jining First People's Hospital

Jianzhong Cui · Tangshan Gongren Hospital

Feng Jin · Affiliated Hospital of Jining Medical University

Ying Cui · Tangshan Gongren Hospital

Ran Li · North China University of Science and Technology

Xiaohua Jiang · North China University of Science and Technology

Yanxia Tian

Abstract

Calcitriol treatment activated VDR protein expression and attenuated neurological deficits in this rat TBI model. The protective effects might be associated with the restoration of autophagy flux and the decrease in apoptosis in the cortex region of rat brain.

Topics & Keywords

Autophagy in Disease and Therapy Vitamin C and Antioxidants Research Adenosine and Purinergic Signaling

UN Sustainable Development Goals

Zero hunger

Publication Details

Published in: PubMed

Volume 42, Issue 5, pp. 1888-1896

DOI: 10.1159/000479571

Field-Weighted Citation Impact: 291.72