18F-Deoxyfluorination of Phenols via Ru π-Complexes

201797 citationsJournal Articlediamond Open Access

Authors

M. Hassan Beyzavi · Harvard University

Debashis Mandal · Harvard University

Martin G. Strebl · Harvard University

Constanze N. Neumann · Harvard University

Erica M. D’Amato · Harvard University

Junting Chen · Max-Planck-Institut für Kohlenforschung

Jacob M. Hooker ·

Abstract

The deficiency of robust and practical methods for 18F-radiofluorination is a bottleneck for positron emission tomography (PET) tracer development. Here, we report the first transition-metal-assisted 18F-deoxyfluorination of phenols. The transformation benefits from readily available phenols as starting materials, tolerance of moisture and ambient atmosphere, large substrate scope, and translatability to generate doses appropriate for PET imaging.

Topics & Keywords

Fluorine in Organic Chemistry Medical Imaging Techniques and Applications Cancer, Hypoxia, and Metabolism

Publication Details

Published in: ACS Central Science

Volume 3, Issue 9, pp. 944-948

DOI: 10.1021/acscentsci.7b00195

Field-Weighted Citation Impact: 4.85

Command Palette

<sup>18</sup>F-Deoxyfluorination of Phenols via Ru π-Complexes

Authors

Abstract

Topics & Keywords

Publication Details