Asymmetric synthesis of chromene skeletons <i>via</i> organocatalytic domino reactions of <i>in situ</i> generated <i>ortho</i>-quinone methide with malononitrile and β-functionalized ketone

Enantioselective organocatalytic domino reactions of <italic>in situ</italic> generated <italic>ortho</italic>-quinone methides with malononitrile and β-functionalized ketones have been developed. This strategy could generate various chiral chromenes in high yields and stereoselectivities.