Anti-inflammatory and immunomodulatory mechanisms of atorvastatin in a murine model of traumatic brain injury

2017237 citationsJournal Articlegold Open Access

Authors

Xin Xu · Tianjin Medical University General Hospital

Weiwei Gao · Ministry of Education of the People's Republic of China

Shiqi Cheng · Nanchang University

Dongpei Yin · Ministry of Education of the People's Republic of China

Fei Li · Ministry of Education of the People's Republic of China

Yingang Wu · Ministry of Education of the People's Republic of China

Dongdong Sun

Abstract

Our data demonstrated that acute atorvastatin administration could modulate post-TBI neuroinflammation effectively, via a mechanism that involves altering peripheral leukocyte invasion and the alternative polarization of microglia/macrophages.

Topics & Keywords

Inflammasome and immune disorders S100 Proteins and Annexins Mitochondrial Function and Pathology

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of Neuroinflammation

Volume 14, Issue 1, pp. 167-167

DOI: 10.1186/s12974-017-0934-2

Field-Weighted Citation Impact: 7.52