Up-regulation of lncRNA CASC9 promotes esophageal squamous cell carcinoma growth by negatively regulating PDCD4 expression through EZH2

2017199 citationsJournal Articlegold Open Access

Authors

Yuanyuan Wu · Army Medical University

Li‐Wen Hu · Southwest Hospital

Yan Liang · Army Medical University

Juan Li · Army Medical University

Kai Wang · Army Medical University

Xuedan Chen · Army Medical University

Hui Meng · Wuhan General Hospital of Guangzhou

Abstract

Our study firstly demonstrates that lncRNA CASC9 functions as an oncogene by negatively regulating PDCD4 expression through recruiting EZH2 and subsequently altering H3K27me3 level. Our study implicates lncRNA CASC9 as a valuable biomarker for ESCC diagnosis and prognosis.

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Publication Details

Published in: Molecular Cancer

Volume 16, Issue 1, pp. 150-150

DOI: 10.1186/s12943-017-0715-7

Field-Weighted Citation Impact: 8.72

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Up-regulation of lncRNA CASC9 promotes esophageal squamous cell carcinoma growth by negatively regulating PDCD4 expression through EZH2

Authors

Abstract

Topics & Keywords

Publication Details