Mesenchymal Stromal Cell Exosomes Ameliorate Experimental Bronchopulmonary Dysplasia and Restore Lung Function through Macrophage Immunomodulation

2017638 citationsJournal Articlegreen Open Access

Authors

Gareth R. Willis · Aalborg University

Angeles Fernandez‐Gonzalez · Aalborg University

Jamie N. Anastas · Harvard University

Sally Vitali · Boston Children's Hospital

Xianlan Liu · Aalborg University

Maria Ericsson · Harvard University

April Kwong ·

Abstract

MSC-exo treatment blunts HYRX-associated inflammation and alters the hyperoxic lung transcriptome. This results in alleviation of HYRX-induced BPD, improvement of lung function, decrease in fibrosis and pulmonary vascular remodeling, and amelioration of pulmonary hypertension. The MSC-exo mechanism of action is associated with modulation of lung macrophage phenotype.

Topics & Keywords

Neonatal Respiratory Health Research Congenital Diaphragmatic Hernia Studies Mesenchymal stem cell research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: American Journal of Respiratory and Critical Care Medicine

Volume 197, Issue 1, pp. 104-116

DOI: 10.1164/rccm.201705-0925oc

Field-Weighted Citation Impact: 48.25