IRX3 Promotes the Browning of White Adipocytes and Its Rare Variants are Associated with Human Obesity Risk

201760 citationsJournal Articlegold Open Access

Authors

Yaoyu Zou · Shanghai Jiao Tong University

Peng Lu · Shanghai Institutes for Biological Sciences

Juan Shi · Shanghai Jiao Tong University

Wen Liu · Shanghai Jiao Tong University

Minglan Yang · Shanghai Jiao Tong University

Shaoqian Zhao · Shanghai Jiao Tong University

Na Chen ·

Abstract

IRX3 deficiency repressed the browning program of white adipocytes partially by regulating UCP1 transcriptional activity. Rare variants of IRX3 were associated with human obesity.

Topics & Keywords

Adipose Tissue and Metabolism Adipokines, Inflammation, and Metabolic Diseases Cardiovascular Disease and Adiposity

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: EBioMedicine

Volume 24, pp. 64-75

DOI: 10.1016/j.ebiom.2017.09.010

Field-Weighted Citation Impact: 3.58