Anesthesia with Dexmedetomidine and Low-dose Isoflurane Increases Solute Transport via the Glymphatic Pathway in Rat Brain When Compared with High-dose Isoflurane

2017229 citationsJournal Articlegreen Open Access

Authors

Helene Benveniste · School of the Art Institute of Chicago

Hedok Lee · School of the Art Institute of Chicago

Fengfei Ding · School of the Art Institute of Chicago

Qian Sun · School of the Art Institute of Chicago

Ehab Al-Bizri · School of the Art Institute of Chicago

Rany Makaryus · School of the Art Institute of Chicago

Stephen Probst

Abstract

We propose that anesthetics affect the glymphatic pathway transport not simply by inducing unconsciousness but also by additional mechanisms, one of which is the repression of norepinephrine release.

Topics & Keywords

Cerebrospinal fluid and hydrocephalus Traumatic Brain Injury and Neurovascular Disturbances Neonatal and fetal brain pathology

Publication Details

Published in: Anesthesiology

Volume 127, Issue 6, pp. 976-988

DOI: 10.1097/aln.0000000000001888

Field-Weighted Citation Impact: 6.69

Command Palette

Anesthesia with Dexmedetomidine and Low-dose Isoflurane Increases Solute Transport via the Glymphatic Pathway in Rat Brain When Compared with High-dose Isoflurane

Authors

Abstract

Topics & Keywords

Publication Details