Hexokinases link DJ-1 to the PINK1/parkin pathway

2017108 citationsJournal Articlegold Open Access

Authors

David N. Hauser · National Institute on Aging

Adamantios Mamais · Institute on Aging

Melissa M. Conti · National Institute on Aging

Christopher T. Primiani · National Institute on Aging

Ravindran Kumaran · National Institutes of Health

Allissa Dillman · National Institutes of Health

Rebekah G. Langston

Abstract

Hexokinases are an important link between three major genetic causes of early onset Parkinson's disease. Because aging is associated with deregulated nutrient sensing, these results help explain why DJ-1 is associated with age-dependent disease.

Topics & Keywords

Parkinson's Disease Mechanisms and Treatments Lysosomal Storage Disorders Research Autophagy in Disease and Therapy

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Molecular Neurodegeneration

Volume 12, Issue 1, pp. 70-70

DOI: 10.1186/s13024-017-0212-x

Field-Weighted Citation Impact: 8.08