Therapeutic inhibition of inflammatory monocyte recruitment reduces steatohepatitis and liver fibrosis

2017527 citationsJournal Article

Authors

Oliver Krenkel · Universitätsklinikum Aachen

Tobias Puengel · Universitätsklinikum Aachen

Olivier Govaere · Newcastle University

Ali T. Abdallah

Jana C. Mossanen · Universitätsklinikum Aachen

Marlene Kohlhepp · Universitätsklinikum Aachen

Anke Liepelt · Universitätsklinikum Aachen

Abstract

Pharmacological inhibition of CCR2<sup>+</sup> monocyte recruitment efficiently ameliorates insulin resistance, hepatic inflammation, and fibrosis, corroborating the therapeutic potential of CVC in patients with NASH. (Hepatology 2018;67:1270-1283).

Topics & Keywords

Liver Disease Diagnosis and Treatment Pancreatitis Pathology and Treatment Liver physiology and pathology

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Hepatology

Volume 67, Issue 4, pp. 1270-1283

DOI: 10.1002/hep.29544

Field-Weighted Citation Impact: 26.58