Landscape of Microsatellite Instability Across 39 Cancer Types

20171,487 citationsJournal Article

Authors

Russell Bonneville · The Ohio State University

Melanie A. Krook · The Ohio State University

Esko A. Kautto · The Ohio State University

Jharna Miya · The Ohio State University

Michele R. Wing · The Ohio State University

Hui‐Zi Chen · The Ohio State University

Julie W. Reeser ·

Abstract

We provide evidence of as-yet-unappreciated MSI in several types of cancer. These findings support an expanded role for clinical MSI testing across multiple cancer types as patients with MSI-positive tumors are predicted to benefit from novel immunotherapies in clinical trials.

Topics & Keywords

Genetic factors in colorectal cancer Cancer Genomics and Diagnostics Lung Cancer Treatments and Mutations

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: JCO Precision Oncology

Volume 2017, Issue 1, pp. 1-15

DOI: 10.1200/po.17.00073

Field-Weighted Citation Impact: 40.39