Comprehensive analysis of mutations in the <i><scp>MEFV</scp></i> gene reveal that the location and not the substitution type determines symptom severity in <scp>FMF</scp>

We found presumptive FMF-causing mutations that did not cluster with DCMs based on their allele frequencies. We also observed that the type of mutation is less likely to determine the severity of the FMF symptoms; rather it was the location of the mutations that was the determining factor.