Evidence for brain glucose dysregulation in Alzheimer's disease

2017498 citationsJournal Articlegreen Open Access

Authors

Yang An · National Institute on Aging

Vijay R. Varma · National Institutes of Health

Sudhir Varma · Systems Analytics (United States)

Ramon Casanova · Wake Forest University

Eric B. Dammer · Emory University

Olga Pletniková · Johns Hopkins University

Chee W. Chia ·

Abstract

Impaired glucose metabolism due to reduced glycolytic flux may be intrinsic to AD pathogenesis. Abnormalities in brain glucose homeostasis may begin several years before the onset of clinical symptoms.

Topics & Keywords

Alzheimer's disease research and treatments Dementia and Cognitive Impairment Research Parkinson's Disease Mechanisms and Treatments

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Alzheimer s & Dementia

Volume 14, Issue 3, pp. 318-329

DOI: 10.1016/j.jalz.2017.09.011

Field-Weighted Citation Impact: 18.97