Refrigeration-Induced Binding of von Willebrand Factor Facilitates Fast Clearance of Refrigerated Platelets

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Authors

Wenchun Chen · University of Arkansas for Medical Sciences

Samuel Druzak · Versiti Blood Center of Wisconsin

Yingchun Wang · University of Arkansas for Medical Sciences

Cassandra D. Josephson · Emory University

Karin M. Hoffmeister · Emory University

Jerry Ware · University of Arkansas for Medical Sciences

Renhao Li

Abstract

Refrigeration-induced binding of VWF to platelets facilitates their rapid clearance by inducing GPIbα-mediated signaling. Our results suggest that inhibition of the VWF-GPIbα interaction may be a potential strategy to enable refrigeration of platelets for transfusion treatment.

Topics & Keywords

Platelet Disorders and Treatments Blood groups and transfusion Blood disorders and treatments

Publication Details

Published in: Arteriosclerosis Thrombosis and Vascular Biology

Volume 37, Issue 12, pp. 2271-2279

DOI: 10.1161/atvbaha.117.310062

Field-Weighted Citation Impact: 4.55

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Refrigeration-Induced Binding of von Willebrand Factor Facilitates Fast Clearance of Refrigerated Platelets

Authors

Abstract

Topics & Keywords

Publication Details