MIR21 Drives Resistance to Heat Shock Protein 90 Inhibition in Cholangiocarcinoma

2017113 citationsJournal Articlehybrid Open Access

Authors

Andrea Lampis · Institute of Cancer Research

Pietro Carotenuto · Institute of Cancer Research

Georgios Vlachogiannis · Institute of Cancer Research

Luciano Cascione · Institute of Oncology Research

Somaieh Hedayat · Institute of Cancer Research

Rosemary Burke · Institute of Cancer Research

Paul A. Clarke

Abstract

miRNA21 appears to mediate resistance of CCA cells to HSP90 inhibitors by reducing levels of DNAJB5. HSP90 inhibitors might be developed for the treatment of CCA and miRNA21 might be a marker of sensitivity to these agents.

Topics & Keywords

Cholangiocarcinoma and Gallbladder Cancer Studies Hepatitis B Virus Studies RNA modifications and cancer

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Gastroenterology

Volume 154, Issue 4, pp. 1066-1079.e5

DOI: 10.1053/j.gastro.2017.10.043

Field-Weighted Citation Impact: 9.92