Amyloid β synaptotoxicity is Wnt‐PCP dependent and blocked by fasudil

2017105 citationsJournal Articlehybrid Open Access

Authors

Katherine J. Sellers · King's College London

Christina Elliott · King's College London

Joshua Jackson · Manchester Academic Health Science Centre

Anshua Ghosh · King's College London

Elena M. Ribé · University of Oxford

Ana I. Rojo · Biomedical Research Networking Center on Neurodegenerative Diseases

Heledd Jarosz-Griffiths

Abstract

Our data add to the importance of aberrant Wnt signaling in Alzheimer's disease neuropathology and indicate that fasudil could be repurposed as a treatment for the disease.

Topics & Keywords

Alzheimer's disease research and treatments Prion Diseases and Protein Misfolding Neuroscience and Neuropharmacology Research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Alzheimer s & Dementia

Volume 14, Issue 3, pp. 306-317

DOI: 10.1016/j.jalz.2017.09.008

Field-Weighted Citation Impact: 4.20