circGFRA1 and GFRA1 act as ceRNAs in triple negative breast cancer by regulating miR-34a

2017378 citationsJournal Articlegold Open Access

Authors

Rongfang He · First Affiliated Hospital of University of South China

Peng Liu · State Key Laboratory of Oncology in South China

Xiaoming Xie · State Key Laboratory of Oncology in South China

Yujuan Zhou · Central South University

Qianjin Liao · Hunan Cancer Hospital

Wei Xiong · Xiangya Hospital Central South University

Xiaoling Li

Abstract

Taken together, we conclude that circGFRA1 may function as a competing endogenous RNA (ceRNA) to regulate GFRA1 expression through sponging miR-34a to exert regulatory functions in TNBC. circGFRA1 may be a diagnostic biomarker and potential target for TNBC therapy.

Topics & Keywords

Circular RNAs in diseases MicroRNA in disease regulation Cancer-related molecular mechanisms research

UN Sustainable Development Goals

No poverty

Publication Details

Published in: Journal of Experimental & Clinical Cancer Research

Volume 36, Issue 1, pp. 145-145

DOI: 10.1186/s13046-017-0614-1

Field-Weighted Citation Impact: 21.49