Antibody-Dependent Cellular Cytotoxicity Responses to Seasonal Influenza Vaccination in Older Adults

201740 citationsJournal Articlebronze Open Access

Authors

Hillary A. Vanderven · Peter Doherty Institute

Sinthujan Jegaskanda · Peter Doherty Institute

Bruce D. Wines · Burnet Institute

P. Mark Hogarth · Burnet Institute

Sarina Carmuglia · Seqirus (United States)

Steven Rockman · Seqirus (United States)

Amy W. Chung ·

Abstract

Older adults commonly have pre-existing ADCC antibodies in the absence of high HAI titers to circulating influenza strains. In older vaccinees, ADCC response mirrored HAI antibodies and was readily detectable despite high postvaccination HAI titers. Alternate measures of vaccine responsiveness and improved vaccinations in this at-risk group are needed.

Topics & Keywords

Influenza Virus Research Studies Animal Disease Management and Epidemiology Respiratory viral infections research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: The Journal of Infectious Diseases

Volume 217, Issue 1, pp. 12-23

DOI: 10.1093/infdis/jix554

Field-Weighted Citation Impact: 3.11