Role of P-Glycoprotein Inhibitors in the Bioavailability Enhancement of Solid Dispersion of Darunavir

201743 citationsJournal Articlehybrid Open Access

Authors

Saleha Rehman · Jamia Hamdard

Bushra Nabi · Jamia Hamdard

Mohammad Fazil · Jamia Hamdard

Saba Khan · Jamia Hamdard

Naimat K. Bari · Institute of Nano Science and Technology

Romi Singh · Sun Pharma (India)

Shavej Ahmad · Sun Pharma (India)

Abstract

It is concluded that SD of DRV with the incorporation of Kolliphor TPGS was potential and promising approach in increasing bioavailability of DRV as well as minimizing its extrusion via P-glycoprotein efflux transporters.

Topics & Keywords

Drug Solubulity and Delivery Systems Advanced Drug Delivery Systems Drug Transport and Resistance Mechanisms

Publication Details

Published in: BioMed Research International

Volume 2017, pp. 1-17

DOI: 10.1155/2017/8274927

Field-Weighted Citation Impact: 1.27

Command Palette

Role of P-Glycoprotein Inhibitors in the Bioavailability Enhancement of Solid Dispersion of Darunavir

Authors

Abstract

Topics & Keywords

Publication Details