Knockdown of SOX2OT inhibits the malignant biological behaviors of glioblastoma stem cells via up-regulating the expression of miR-194-5p and miR-122

2017165 citationsJournal Articlegold Open Access

Authors

Rui Su · China Medical University

Shuo Cao · China Medical University

Jun Ma · China Medical University

Yunhui Liu · Shenyang Center for Disease Control and Prevention

Xiaobai Liu · China Medical University

Jian Zheng · China Medical University

Jiajia Chen ·

Abstract

This study is the first to demonstrate that the SOX2OT-miR-194-5p/miR-122-SOX3-TDGF-1 pathway forms a positive feedback loop and regulates the biological behaviors of GSCs, and these findings might provide a novel strategy for glioma treatment.

Topics & Keywords

MicroRNA in disease regulation Circular RNAs in diseases Cancer-related molecular mechanisms research

Publication Details

Published in: Molecular Cancer

Volume 16, Issue 1, pp. 171-171

DOI: 10.1186/s12943-017-0737-1

Field-Weighted Citation Impact: 6.32

Command Palette

Knockdown of SOX2OT inhibits the malignant biological behaviors of glioblastoma stem cells via up-regulating the expression of miR-194-5p and miR-122

Authors

Abstract

Topics & Keywords

Publication Details