Association of Polygenic Score for Schizophrenia and HLA Antigen and Inflammation Genes With Response to Lithium in Bipolar Affective Disorder

2017148 citationsJournal Articlebronze Open Access

Authors

Azmeraw T. Amare · University of Adelaide

Klaus Oliver Schubert · University of Adelaide

Liping Hou · United States Department of Health and Human Services

Scott R. Clark · University of Adelaide

Sergi Papiol · Ludwig-Maximilians-Universität München

Urs Heilbronner · Ludwig-Maximilians-Universität München

Franziska Degenhardt

Abstract

This study provides evidence for a negative association between high genetic loading for SCZ and poor response to lithium in patients with BPAD. These results suggest the potential for translational research aimed at personalized prescribing of lithium.

Topics & Keywords

Bipolar Disorder and Treatment Adolescent and Pediatric Healthcare Genetic Associations and Epidemiology

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: JAMA Psychiatry

Volume 75, Issue 1, pp. 65-74

DOI: 10.1001/jamapsychiatry.2017.3433

Field-Weighted Citation Impact: 13.23