EZH2 suppression in glioblastoma shifts microglia toward M1 phenotype in tumor microenvironment

201787 citationsJournal Articlegold Open Access

Authors

Yatao Yin · Sun Yat-sen Memorial Hospital

Shuwei Qiu · Nanjing Drum Tower Hospital

Xiangpen Li · Sun Yat-sen University

Bo Huang · Sun Yat-sen University

Yun Xu · Nanjing Drum Tower Hospital

Ying Peng · Sun Yat-sen Memorial Hospital

Abstract

Our data demonstrates that EZH2 participates in GBM-induced immune deficient and EZH2 suppression in GBM can remodel microglia immune functions, which is beneficial for understanding GBM pathogenesis and suggests potential targets for therapeutic approaches.

Topics & Keywords

Immune cells in cancer Neuroinflammation and Neurodegeneration Mechanisms Epigenetics and DNA Methylation

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of Neuroinflammation

Volume 14, Issue 1, pp. 220-220

DOI: 10.1186/s12974-017-0993-4

Field-Weighted Citation Impact: 2.35