RNA N6‐methyladenosine methyltransferase‐like 3 promotes liver cancer progression through YTHDF2‐dependent posttranscriptional silencing of SOCS2

20171,517 citationsJournal Article

Authors

Mengnuo Chen · University of Hong Kong

Lai Wei · University of Hong Kong

Cheuk‐Ting Law · University of Hong Kong

Felice Ho‐Ching Tsang · University of Hong Kong

Jialing Shen · University of Hong Kong

Carol Lai‐Hung Cheng · University of Hong Kong

Long‐Hin Tsang ·

Abstract

METTL3 is frequently up-regulated in human HCC and contributes to HCC progression. METTL3 represses SOCS2 expression in HCC through an m6A-YTHDF2-dependent mechanism. Our findings suggest an important mechanism of epigenetic alteration in liver carcinogenesis. (Hepatology 2018;67:2254-2270).

Topics & Keywords

RNA modifications and cancer Cancer-related molecular mechanisms research RNA Research and Splicing

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Hepatology

Volume 67, Issue 6, pp. 2254-2270

DOI: 10.1002/hep.29683

Field-Weighted Citation Impact: 42.20