Mesenchymal stem cell-derived extracellular vesicles attenuate pulmonary vascular permeability and lung injury induced by hemorrhagic shock and trauma

201796 citationsJournal Article

Authors

Daniel Potter · Maryland Institute College of Art

Byron Miyazawa · Maryland Institute College of Art

Stuart L. Gibb · Maryland Institute College of Art

Xutao Deng · Maryland Institute College of Art

Padma P. Togaratti · Maryland Institute College of Art

Roxanne H. Croze · Maryland Institute College of Art

Amit K. Srivastava

Abstract

Mesenchymal stem cells and MSC EVs modulate cytoskeletal signaling and attenuate lung vascular permeability after HS. Mesenchymal stem cell EVs may potentially be used as a novel "stem cell free" therapeutic to treat HS-induced lung injury.

Topics & Keywords

Extracellular vesicles in disease Trauma and Emergency Care Studies Heme Oxygenase-1 and Carbon Monoxide

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: The Journal of Trauma: Injury, Infection, and Critical Care

Volume 84, Issue 2, pp. 245-256

DOI: 10.1097/ta.0000000000001744

Field-Weighted Citation Impact: 3.69