Adaptive Servo-Ventilationf for Central Sleep Apnoea in Systolic Heart Failure: Results of the Major Substudy of SERVE-HF

In patients with systolic heart failure and CSA, addition of ASV to guideline-based medical management had no statistically significant effect on cardiac structure and function, or on cardiac biomarkers, renal function and systemic inflammation over 12 months. The increased cardiovascular mortality reported in SERVE-HF may not be related to adverse remodelling or worsening heart failure.