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Objective: Previous studies have demonstrated the effects of positive psychological \nfactors on pain adjustment. Specifically, optimism has been linked to better physical \nfunctioning and less psychological distress. Until recently, these beneficial effects have \nmostly been examined in correlational studies or laboratory settings. The aim of this \nstudy is to test the efficacy of the Best Possible Self intervention using information and \ncommunication technologies with fibromyalgia patients. \nMethods: Seventy-one patients were randomly allocated to the Best Possible Self \nintervention or a Daily Activities control condition. The Best Possible Self intervention \nused an interactive multimedia system with the support of an Internet platform to \npractice the guided imagery exercise online. \nResults: Intent-to-treat analyses showed that, compared to the control condition, Best \nPossible Self patients showed significant improvements in depression, positive affect, \nand self-efficacy at post-intervention. Moreover, at 3-month follow-up, patients that \nreceived the intervention improved their optimism and negative affect significantly \nmore than participants in the control condition. \nDiscussion: This study shows how a technology-supported intervention aimed at \naugmenting positive affect and promoting positive functioning works in the case of \nfibromyalgia, expanding the intervention’s efficacy data in clinical populations and \nadding knowledge about the role that positive psychological factors play in pain \nexperience. Moreover, it demonstrates the specific effects of the Best Possible Self \nintervention in order to incorporate this exercise in pain treatment protocols.